Silica powder update#

The results of our meta-analysis supported the carcinogenic role of silica on the lungs, which was more pronounced at higher levels of exposure, in the presence of silicosis and in the mining industry. A positive exposure-response relation was found between cumulative silica exposure and risk of lung cancer. Subgroup analysis showed that workers in the mining industry had the highest risk of lung cancer with a pooled SMR of 1.48 (95 % CI 1.18–1.86) and the weakest association was seen in potteries with a pooled SMR of 1.14 (95 % CI 1.05–1.23). The pooled standardized mortality ratio (SMR) was 2.32 with a 95 % confidence interval (95 % CI) of 1.91–2.81 and 1.78 (95 % CI 1.07–2.96) respectively. The risk of lung cancer was found to be elevated in both silicotics and non-silicotics. Studies which had adequate exposure characterization were selected to find out whether there was an exposure-response relationship between silica and lung cancer. Subgroup and meta-regression analyses (both univariate and multivariate) were performed in an attempt to explain heterogeneity. Due to the significant amount of heterogeneity expected, random effects models were implemented. Studies reporting results according to silicotic status were grouped together and analyzed. Cohort, case control and proportional mortality studies were examined separately. Pooled effect estimates were calculated according to the reported outcome and the study design. MethodsĮligible studies up to 29 April 2016 were identified.

Silica powder update#

Our objectives are to review and summarize the epidemiological evidence on the relationship between occupational silica exposure and risk of lung cancer and to provide an update on this major occupational health concern. Although its association with lung cancer has been studied for many decades, the conclusion remains somewhat controversial. Crystalline silica is considered as one of the most common and serious occupational hazards to workers’ health.